Which Scenario Is Representative of a Multifactorial Disease

question 61

Multiple Choice

Which scenario is representative of a multifactorial disease?

• A) The gene responsible for the disease contains a triplet sequence, CGG, in the promotor region, which is repeated 500 times.
• B) There is loss of function of a normal tumor suppressor gene, followed by abnormal cell growth, activation of an oncogene, continued abnormal cell growth, and loss of function of additional tumor suppressor genes, ultimately leading to cancer.
• C) Parts of chromosomes 10 and 19 are swapped (translocated), and as a result, gene A on chromosome 10 becomes fused with gene B on chromosome 19, resulting in a gain-of-function mutation causing uncontrolled cell division.
• D) A point mutation leading to a frame-shift mutation in gene A results in the production of a nonfunctional protein.
• E) A chromosome breaks at two points and then rejoins, leaving out the DNA between the breaks, thus resulting in a deletion of gene A.

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Definitions:

Wilcoxon Rank Sum Test

A non-parametric statistical test used to compare two independent samples to assess whether their population mean ranks differ.

Wilcoxon Rank-sum Test

A nonparametric statistical test used to compare two independent samples to determine if they come from the same population or not, based on rank sums.

Wilcoxon Rank Sum Test

A non-parametric statistical test used to compare two independent samples to assess whether their populations have identical distribution.

Sign Test

A non-parametric statistical test used to assess the difference between matched pairs of samples when the specific data measurement scale does not meet the requirements for parametric testing.