Adenosine Deaminase (ADA) Deficiency Is a Severe Form of Immunodeficiency

question 120

Multiple Choice

Adenosine deaminase (ADA) deficiency is a severe form of immunodeficiency that is usually fatal because of the greatly diminished ability of homozygous individuals to fight off bacterial and viral infections.The enzyme is necessary for the removal of the toxic metabolic product deoxyadenosine that is produced in T and B lymphocytes.Both T and B lymphocytes are produced by bone marrow stem cells, which can be harvested from patients.To restore T and B lymphocytes, a few children have been successfully treated for ADA with gene therapy, which would have been _______ gene therapy, given the above information.

• A) in vivo somatic cell
• B) gamete cell
• C) ex vivo somatic cell
• D) in vivo germ line
• E) ex vivo germ line

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Definitions:

Projected Benefit Obligation

An estimate of the total amount of benefits to be paid out to employees in a defined benefit pension plan, based on current and future salary levels.

Discount Rate

The interest rate used in discounted cash flow (DCF) analysis to determine the present value of future cash flows, reflecting the risk and time value of money.

Pension Expense

The cost recognized by an employer for maintaining a pension plan for its employees during a reporting period.

Pension Obligations

These are liabilities companies face for the pension benefits they have promised to pay their employees in the future.