An Enzyme Is Required to Convert the Inactive Form of a Drug

question 127

Multiple Choice

An enzyme is required to convert the inactive form of a drug into the active form.A completely dominant change from the G to the C allele increases activity of the enzyme.Too much of the active form of the drug can lead to tremors.Too little of the active form of the drug renders it ineffective.Which scenario is most likely?

• A) Individuals with the GC genotype are more likely to have tremors from the drug than those with CC.
• B) Individuals with the GC genotype are more likely to have tremors from the drug than those with GG.
• C) The drug is more likely to be ineffective in individuals with the GC genotype than in those with GG.
• D) The drug is more likely to be just as effective in individuals with the GC genotype as in those with CC.
• E) The drug is less likely to be ineffective in individuals with the GG genotype than those with GC.

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Definitions:

Citric Acid Cycle

The citric acid cycle, also known as the Krebs cycle or TCA cycle, is a series of chemical reactions used by all aerobic organisms to generate energy through the oxidation of acetate derived from carbohydrates, fats, and proteins into carbon dioxide.

Acetyl CoA

A molecule that plays a key role in metabolism, linking glycolysis and beta-oxidation to the citric acid cycle; essential for the production of energy from food.

CO2

A greenhouse gas present in the Earth's atmosphere, consisting of two oxygen atoms covalently bonded to a single carbon atom, vital for life processes like photosynthesis.

Phosphofructokinase

An enzyme that plays a critical role in regulating the rate of glycolysis, controlling the conversion of fructose 6-phosphate to fructose 1,6-bisphosphate.