Refer to the Table

question 187

Multiple Choice

Refer to the table.In mice, a single-gene mutation can lead to obesity.The Ob gene codes for the protein leptin.The recessive ob allele is a loss-of-function allele, so ob/ob mice do not produce leptin and they become obese.In an experiment, leptin was injected into ob/ob and Ob/Ob (wild-type) mice daily.The data in the table below were collected before the injections began (baseline) and 10 days later.(Assume that the Ob allele is dominant.) Researchers found that levels of the hormone leptin are high in the bloodstreams of most overweight humans.Based on the data in the table from the experiment on mice, what is a likely explanation for this observation in humans?

• A) All the humans in the study were male.
• B) The overweight individuals were ob/ob.
• C) The overweight individuals were Ob/ob.
• D) The leptin receptors in the overweight individuals had reduced sensitivity to leptin.
• E) The individuals in the study lacked the leptin gene.

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