Aripiprazole (Abilify) Has Been Called a Third-Generation Antipsychotic

question 14

Multiple Choice

Aripiprazole (Abilify) has been called a third-generation antipsychotic.What is a major difference in its pharmacological profile from that of 1^st and 2^nd generation antipsychotic drugs?

• A)Abilify blocks 5-HT2A receptors, whereas 1st and 2^nd generation antipsychotic drugs act as agonists at 5-HT2A receptors
• B)Abilify blocks dopamine D2 receptors, whereas 1^st and 2^nd generation antipsychotic drugs act as agonists at dopamine D2 receptors
• C)Abilify is a partial agonist at dopamine D2 receptors, whereas 1^st and 2^nd generation antipsychotic drugs act as antagonists or inverse agonists at dopamine D2 receptors

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