Two Groups of Rats Have a Small Pellet Implanted Under

question 4

Essay

Two groups of rats have a small pellet implanted under the skin.In Group A rats the pellet contains morphine, which is slowly absorbed over a 72 hour period.In Group B rats the pellet contains an inert substance.The rats are kept in their home cages for the three days after the pellet implantation.Both groups are then tested for analgesia by being injected intraperitoneally with a small dose of morphine.This test consists of the rats being placed on a hot surface and they are timed to see how long it takes them to lick their paws.(It is assumed that the longer it takes the rats to lick their paws, the more the analgesia.) Group A rats display much less of an analgesic response than Group B rats.Is this tolerance phenomenon more compatible with a pharmacodynamic or a context specific mechanism for tolerance development? Explain your reasoning.

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Definitions:

Predicate

The part of a sentence or proposition that tells something about the subject, such as an action, condition, or effect.

Categorical Proposition

A proposition containing a subject and a predicate term and asserting that some or all of the referents of the subject term are included in or excluded from the class designated by the predicate term.

Predicate Class

A category of predicates that share common characteristics in their formulation or application.

Right Direction

In causal inference, refers to the correct identification of the direction of causality between variables.