Find the derivative of the given function. Simplify and express the answer using positive exponents only. 
Definitions:
Miami Indians
A Native American tribe originally located in the Great Lakes region, known for their roles in various historical conflicts and their adaptation to changing environments.
Smallpox Epidemic
A devastating outbreak of the smallpox disease, which, before its eradication, caused millions of deaths worldwide and shaped human history through its impact on communities and civilizations.
Rendezvous
A prearranged meeting place, often used in historical contexts to describe gatherings of fur traders and mountain men in the American West.
Fur Trappers
Individuals who catch and kill animals primarily for their fur, historically significant in the North American fur trade.
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