There Is Often Cross-Sensitivity and Cross-Resistance Between Penicillins and Cephalosporins

question 2

Multiple Choice

There is often cross-sensitivity and cross-resistance between penicillins and cephalosporins because:

• A) Renal excretion is similar in both classes of drugs.
• B) When these drug classes are metabolized in the liver they both produce resistant enzymes.
• C) Both drug classes contain a beta-lactam ring that is vulnerable to beta-lactamase-producing organisms.
• D) There is not an issue with cross-resistance between the penicillins and cephalosporins.

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