Rifampin Is a Nonspecific CYP450 Inducer That May

question 8

Multiple Choice

Rifampin is a nonspecific CYP450 inducer that may:

• A) Lead to toxic levels of rifampin and must be monitored closely
• B) Cause toxic levels of drugs, such as oral contraceptives, when coadministered
• C) Induce the metabolism of drugs, such as oral contraceptives, leading to therapeutic failure
• D) Cause nonspecific changes in drug metabolism

Describe the significance of resonance structures in understanding the stability of intermediates in electrophilic aromatic substitution reactions.

Explain the rate-determining step in electrophilic aromatic substitution reactions.

Demonstrate the ability to predict the reactivity of different aromatic compounds towards electrophilic substitution reactions.

Sketch mechanisms for electrophilic aromatic substitution reactions based on given reactants.