Chronic Myelogenous Leukemia (CML) Results from a Translocation Between Human

question 16

Multiple Choice

Chronic myelogenous leukemia (CML) results from a translocation between human chromosomes 9 and 22. The resulting chromosome 22 is significantly shorter than usual, and it is known as a Philadelphia (Ph') chromosome. The junction at the site of the translocation causes overexpression of a receptor tyrosine kinase. A new drug (Gleevec or imatinib) has been found to inhibit the disease if the patient is treated early. Which of the following would be a reasonably efficient technique for confirming the diagnosis of CML?

• A) searching for the number of telomeric sequences on chromosome 22
• B) looking for a Ph' chromosome in a peripheral blood smear
• C) enzyme assay for receptor tyrosine kinase activity
• D) fluorescent labeling to determine the chromosomal location of all chromosome 22 fragments
• E) identification of the disease phenotype in review of the patient's records

Identify the structure and focus of effective sales messages, including the number of selling points to maintain reader interest.

Distinguish between the characteristics of online sales messages and direct-mail messages.

Apply the appropriate organizational strategy in writing persuasive requests.

Understand the use and effectiveness of rational appeals in sales messages.

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Definitions:

Americas

The continents of North and South America, including their associated islands and territories, often referred to collectively.

Autobiographical Account

A narrative or work that an individual writes about their own life experiences.

Eighteenth Century

The eighteenth century encompasses the period from January 1, 1701, through December 31, 1800, characterized by significant developments in politics, philosophy, science, and the arts.

Bartolomé de Las Casas

A 16th-century Spanish friar, historian, and advocate for the rights and dignity of Native Americans, denouncing their oppression and exploitation by Europeans.