Which of the Following Most Correctly Describes the Whole-Genome Shotgun

question 23

Multiple Choice

Which of the following most correctly describes the whole-genome shotgun technique for sequencing a genome?

• A) genetic mapping followed immediately by sequencing
• B) physical mapping followed immediately by sequencing
• C) cloning large genome fragments into very large vectors such as YACs, followed by sequencing
• D) cloning fragments from many copies of an entire chromosome, sequencing the fragments, and then ordering the sequences
• E) cloning the whole genome directly, from one end to the other

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