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Scenario I
The following scenario is based on and presents fabricated data consistent with the following study:
Caspi,A. ,Sugden,K. ,Moffitt,T.E. ,Taylor,A. ,Craig,I.W. ,Harrington,H. ,McClay,J. ,Mill,J. ,Martin,J. ,Braithwaite,A. ,and Poulton,R.(2003) .Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene.Science,301(5631) ,386-389.
The serotonin transporter gene codes for the serotonin transporter,a protein that transports serotonin from the synapse to the presynaptic neuron.Several polymorphisms of the gene exist,including a "short" (s) and a "long" (l) variation.As humans receive one copy of the gene from each parent,people can be grouped into three groups based on this genetic variation: s/s (two copies of the short gene) ,s/l,and l/l.Caspi et al.(2003) interviewed participants in each of these groups and asked them a wide range of questions to determine both the degree of exposure to stress and the number of depressive episodes participants had experienced in their lives.Fabricated results consistent with their major findings are shown in Figure 3.1.
Figure 3.1
-(Scenario I) An individual has two copies of the small variation of the serotonin transporter gene and has been exposed to a high degree of stress over the course of her lifetime.Based on the results shown in the scenario,one could:
Maderno's Design
The architectural plan by Carlo Maderno for the façade and extension of St. Peter's Basilica in Vatican City, which marked the transition from Renaissance to Baroque architecture.
Santa Susanna
A historic Catholic church in Rome, Italy, known for its Late Renaissance architecture and considered a titular church with a long history.
Pope Paul V
The head of the Roman Catholic Church and ruler of the Papal States from 1605 to 1621, known for his role in the Counter-Reformation and his support of the arts.
Maderno
A reference to Carlo Maderno, an Italian architect who is considered one of the pioneers of Baroque architecture in the early 17th century.
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