Complete the following reaction sequence,giving structural details of all significant intermediates and the final product. 
Definitions:
Geographic Differences
Variations in cultural, environmental, economic, and social characteristics across different regions or territories.
Dementia Rates
The incidence or prevalence of dementia in a population, indicating how common the condition is within a specific demographic or over time.
Centenarians
Individuals who have reached the age of 100 years or more.
Alzheimer's Disease
A progressive neurological disorder that causes memory loss, cognitive decline, and eventually, loss of ability to carry out daily activities, leading to complete dependency on caregivers.
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