Why Is the Imidazole R-Group of Histidine a Particularly Versatile

question 49

Multiple Choice

Why is the imidazole R-group of histidine a particularly versatile amino acid side chain in terms of its involvement in enzymatic reaction mechanisms?

• A) It is strongly involved in specific acid-base catalysis.
• B) It acts as a strong electrophile.
• C) It disrupts H-bonds and stabilizes exposed peptide residues.
• D) It acts as a strong nucleophile as well as a general acid or base.
• E) It contains a high energy phosphate bond.

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