Why Does a Polymorphism in CYP2D6 Decrease the Efficacy of Codeine

question 47

Multiple Choice

Why does a polymorphism in CYP2D6 decrease the efficacy of codeine?

• A) Alters the number of AhR
• B) Decreases uptake of codeine by the brain
• C) Increases excretion of codeine
• D) Increases Phase II metabolism
• E) Slows formation of morphine

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Definitions:

Chromalveolates

A supergroup composed of diverse protists with few shared characters; most are photosynthetic, and heterotrophic chromalveolates, such as the water molds and ciliates, probably descended from autotrophic ancestors. Divided into two main groups; see alveolates and stramenopiles.

Euglenoids

A group of mostly freshwater unicellular excavates that move by means of an anterior flagellum and are usually photosynthetic.

Coenocytic

Refers to a type of cell or organism that has multiple nuclei sharing a common cytoplasm, without being divided into individual cells.

Multiple Nuclei

A condition where a cell contains more than one nucleus, common in certain types of muscle cells and some fungal species.