Cyclic AMP Can Activate the Synthesis of Some Enzymes

question 77

Multiple Choice

Cyclic AMP can activate the synthesis of some enzymes. It is likely that the mechanism involves

• A) binding of free cAMP to a nucleotide sequence in the promoter region of the gene for the enzyme.
• B) phosphorylation of an acidic protein which is bound to the gene for the enzyme.
• C) phosphorylation of a glucocorticoid receptor protein which then migrates to the nucleus and activates the gene for the enzyme.
• D) binding of cAMP to a protein kinase regulatory subunit which migrates to the nucleus, binds to chromatin, and activates the gene for the protein.
• E) phosphorylation of initiation factor IF-2 which stimulates translation of the mRNA for the enzymes.

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