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Explain Why Acylation of Active Methylene Compounds Must Be Carried

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Essay

Explain why acylation of active methylene compounds must be carried out in aprotic solvents,typically using NaH to generate the enolate anion: why can sodium ethoxide/ethanol not be used in these reactions?


Definitions:

Spinal Nerves

Nerves that originate from the spinal cord and branch out to various parts of the body, transmitting signals between the brain and the rest of the body.

Sensory Fibers

Nerve fibers that transmit sensory information from the body to the central nervous system.

Motor Fibers

Nerve fibers that transmit impulses from the brain or spinal cord to muscles or glands, orchestrating their movement or activity.

Schwann Cells

The principal glia of the peripheral nervous system, responsible for the formation of myelin.

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