The Appropriate Sequence for Ubiquitination of Proteins to Be Degraded

question 6

Multiple Choice

The appropriate sequence for ubiquitination of proteins to be degraded is:
A.multiple ubiquitinations may occur on a protein substrate,
B.ubiquitin-protein ligase (E₃) transfers ubiquitin to free amino groups on the protein,
C.E₃ selects a protein for degradation by the nature of the N-terminal amino acid,
D.ubiquitin-carrier protein (E₂) picks up ubiquitin,
E.ubiquitin-activating enzyme (E₁) attaches via ATP-dependent formation of thioester bond to C-termini of ubiquitin,

• A) A, C, B, D, E
• B) E, D, A, B, C
• C) D, E, C, A, B
• D) C, E, D, B, A
• E) E, D, C, B, A

---

Definitions:

Jumping

The action of propelling oneself into the air through the forceful extension of the legs, often used in sports, exercise, or as a means of bypassing obstacles.

Firearms

Portable weapons that launch one or more projectiles driven by rapidly expanding high-pressure gas produced chemically by propellant combustion.

Suicide Rate

A statistical measure representing the number of suicide deaths in a specified population or area over a given timeframe.

Married Persons

Individuals who are legally joined in matrimony, a state that entails certain legal rights, responsibilities, and social recognition.