Which of the Following Statements Explains Why Methotrexate Is Effective

question 25

Multiple Choice

Which of the following statements explains why methotrexate is effective as a cancer chemotherapeutic?

• A) it serves as an analog of p-aminobenzoic acid and block bacterial synthesis of folate
• B) acts as an inhibitor of dihydrofolate reductase, thus preventing production of tetrahydrofolate
• C) it acts as a suicide substrates for the enzyme dihydropteroate synthetase
• D) prevents the conversion of N⁵,N¹⁰-methenyl THF to N¹⁰-formyl THF which is required in 2 steps of the purine synthesis pathway
• E) both b and d are correct

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Definitions:

Disease Process

The series of events related to the development and progression of a disease, including its onset, symptoms, and effects on the body.

Medial

Pertaining to or situated toward the midline of the body or an organ.

Lateral

Pertaining to or situated at the side.

Abdominopelvic Cavity

A body cavity comprising the abdominal and pelvic cavities, housing major organs of digestion, reproduction, and excretion.