A Molecule Such as 2,4-Dinitrophenol Works to Uncouple the Proton

question 23

Multiple Choice

A molecule such as 2,4-dinitrophenol works to uncouple the proton gradient. Which of the following is true about 2,4-DNP?

• A) 2,4-DNP is protonated in the matrix and deprotonated in the intermembrane space.
• B) The presence of an uncoupler results in an increase in the activity of the TCA cycle and electron transport
• C) 2,4-DNP is a very ineffective uncoupler because its hydrophobic structure prevents it from effectively crossing lipid bilayer membranes.
• D) 2,4-DNP has been used as a very effective diet aid for the past 70 years
• E) none of the above are correct