How Does PTEN Affect the Balance Between Proapoptotic and Antiapoptotic

question 56

Multiple Choice

How does PTEN affect the balance between proapoptotic and antiapoptotic signals?

• A)PTEN removes the phosphate group from the 3-position of PIP₃ converting it to PI(4,5)P₂,which cannot activate PKB (AKT)and thus throws the balance in an antiapoptotic direction.
• B)PTEN removes the phosphate group from the 3-position of PIP₃ converting it to PI(4,5)P₂,which cannot activate PKB (AKT)and thus throws the balance in a proapoptotic direction.
• C)PTEN cuts a phosphate group off of PKB,which throws the balance in a proapoptotic direction.
• D)PTEN cuts a phosphate group off of PKB,which throws the balance in an antiapoptotic direction.
• E)PTEN adds a phosphate group to PKB,which throws the balance in a proapoptotic direction.

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