Why Does the Activation of a Protein Kinase That Acts

question 4

Multiple Choice

Why does the activation of a protein kinase that acts on initiation factor eIF2 block protein synthesis?

• A)Phosphorylated eIF2 denatures.
• B)Phosphorylated eIF2 cannot exchange its GDP for GTP, which is required for eIF2 to participate in another round of translation initiation.
• C)Phosphorylated eIF2 cannot exchange its GTP for GDP, which is required for eIF2 to participate in another round of translation initiation.
• D)Phosphorylated eIF2 is hyperactivated, blocking further translation.
• E)Dephosphorylated eIF2 cannot exchange its GDP for GTP, which is required for eIF2 to participate in another round of translation initiation.

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Definitions:

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