CTLA-4,expressed by Regulatory T Cells and Activated Effector T Cells,is

question 10

Multiple Choice

CTLA-4,expressed by regulatory T cells and activated effector T cells,is crucial for self-tolerance as well as regulation of T cell responses of foreign antigens.Which of the following is a property of CTLA-4 that is important for its function?

• A)CTLA-4 binds to CD28 and blocks its function.
• B)CTLA-4 binds B7-1 and B7-2 with high affinity blocking their binding to CD28.
• C)CTLA-4 binds class I MHC and blocks it ability to bind peptides.
• D)CTLA-4 binds IL-2,preventing IL-2 binding to the IL-2 receptor.
• E)CTLA-4 binds to IgG,preventing IgG biding to antigens.

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