Abatacept Is a Biologic Drug That Is a Fusion Protein

question 15

Multiple Choice

Abatacept is a biologic drug that is a fusion protein formed from the B7-binding domain of CTLA-4 fused to the human IgG1 constant region. In patients suffering from rheumatoid arthritis (RA) , high levels of granzyme B in the synovial fluid of inflamed joints is thought to contribute to joint erosion. When treated with abatacept, a subset of patients shows significant improvement in their RA symptoms together with decreased levels of granzyme B in their affected joints. These data indicate that the granzyme B found in RA patients' inflamed joints is predominantly made by:

• A) Antigen-presenting cells such as dendritic cells
• B) Activated macrophages
• C) Effector T cells
• D) FoxP3+ T_reg cells
• E) Neutrophils

---

Definitions:

Developed Countries

Nations with relatively high levels of economic prosperity and standards of living, often characterized by high Gross Domestic Product (GDP) per capita.

Income Inequality

The unequal distribution of income within a population, often measured by various statistical means, indicating the gap between the rich and the poor.

Developed Countries

Nations with high levels of industrialization, a higher standard of living, advanced technological infrastructure, and more complex economic systems compared to developing countries.

Poverty Line

An absolute level of income set by the federal government for each family size below which a family is deemed to be in poverty.