Studies in Mice Have Revealed Important Features About Some Chronic

question 10

Multiple Choice

Studies in mice have revealed important features about some chronic infections. In the case of mice infected with a persistent strain of lymphocytic choriomeningitis virus (LCMV) , these studies showed that a majority of the virus-specific T cells were eliminated from the mice over time; however, some virus-specific CD8 T cells persisted but were unable to eradicate the viral infection. These remaining cells expressed high levels of several inhibitory receptors, including PD-1. One possible treatment for these mice to promote their ability to clear this chronic infection would be:

• A) Immunization with an inactivated preparation of LCMV
• B) Administration of anti-PD-1 antibody
• C) Administration of an antiviral drug that would block LCMV replication
• D) Immunization with a purified surface antigen from LCMV
• E) Stimulation with a TLR7 or TLR9 ligand to induce an interferon response

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Definitions:

Essential Self

The core or fundamental aspect of an individual that defines their true nature or identity, often distinguished from external influences or social constructs.

Descriptions

The act of explaining or detailing the characteristics or features of something.

Hegel

G. W. F. Hegel was a German philosopher who developed a comprehensive philosophical framework known for its dialectical method, emphasizing the progress of history and consciousness.

Marx

A revolutionary thinker and philosopher, Karl Marx, known for his critical analysis of capitalism and his contributions to the development of Marxist theory.