Muckle-Wells Syndrome Is an Autosomal Dominantly Inherited Disease Due to Mutations

question 6

Essay

Muckle-Wells syndrome is an autosomal dominantly inherited disease due to mutations in NLRP3. Individuals with this disease suffer from episodes of fever, as well as urticarial rash, joint pains, and conjunctivitis. What is the explanation for the beneficial effects of anakinra (IL-1 receptor antagonist) treatment in these patients?

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Definitions:

Vitamin C

An essential nutrient that serves as an antioxidant and is necessary for the production of collagen, healing wounds, and maintaining healthy bones and teeth.

Withdrawal

A physical and psychological aspect of addiction that occurs when a person experiences anxiety, tension, and cravings after stopping use of an addictive drug.

Tolerance

A physical aspect of addiction that occurs when a person needs to take larger doses of a drug to experience its effect.

Psychological Dependence

The emotional or mental attachment to a substance, behavior, or habit, characterized by a perceived need for the substance or behavior to function normally.