In the Late 1990s, a Group of Individuals Was Discovered

question 21

Multiple Choice

In the late 1990s, a group of individuals was discovered that remained uninfected with HIV, in spite of multiple exposures to the virus. Analysis indicated that these HIV-resistant individuals had a homozygous deficiency caused by a 32-bp deletion in a single gene, and furthermore, that this mutation was present at a frequency of ~10% (in heterozygous form) in individuals of European descent. These data provided clear evidence indicating that:

• A) Healthy individuals can have a genetic deficiency in the expression of CD4.
• B) Testing for HIV by seroconversion does not identify all infected individuals.
• C) HIV infection requires a co-receptor in addition to CD4.
• D) Some individuals can be infected with HIV but not develop AIDS.
• E) Both R5 and X4 variants of HIV are equally important in HIV transmission.

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Definitions:

Corporate Executives

High-ranking officers within a corporation who are responsible for making critical decisions, steering the company's strategy, and managing organizational operations.

College Business Students

Individuals pursuing academic studies in business disciplines at a college or university.

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Educational leaders who manage the operations of a high school, including academic programs, staff, and student policies.

Army Officers

Military personnel who hold positions of authority and command within an army, responsible for leading and managing soldiers.