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The Fc Receptor FcRn, Expressed in Intestinal Epithelial Cells, Binds

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Essay

The Fc receptor FcRn, expressed in intestinal epithelial cells, binds to the Fc portion of IgG antibodies. Moreover, FcRn binds to IgG with high affinity at an acidic pH (<6.5) but not at physiological pH (pH 7.4). How is this biochemical feature of FcRn critical for its role in antigen presentations for gut immunity?


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