Infection of Mice with the Bacterial Pathogen, Citrobacter Rodentium, Elicits

question 7

Multiple Choice

Infection of mice with the bacterial pathogen, Citrobacter rodentium, elicits a protective immune response in the gastrointestinal tract. This protective response is characterized by two sequential waves of IL-22 production, both induced by IL-23. The early wave of IL-22 production (<day 8 post-infection) is likely produced by:

• A) Lamina propria dendritic cells responding to PAMPs of the bacterial pathogen
• B) Lamina propria macrophages responding to PAMPs of the bacterial pathogen
• C) Naive CD4 T cells induced to differentiate into T_H17 cells in the mesenteric lymph node
• D) Lamina propria ILC3 cells stimulated by dendritic cell-produced IL-23
• E) IgA immune complexes transporting bacterial antigens and stimulating lamina propria dendritic cells to produce IL-22

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