In Response to an Intracellular Bacterial or Viral Infection, Effector $\gamma$

question 19

Multiple Choice

In response to an intracellular bacterial or viral infection, effector T_H1 cells, macrophages, NK cells, and CD8 cytotoxic effector cells are all recruited to the site of infection. The coordinated recruitment of all of these cell types is orchestrated by:

• A) The secretion of the inflammatory cytokine IFN-\(\gamma\) in the tissue
• B) The action of TNF-\(\alpha\) on the endothelial cells, leading to fluid leakage into the tissue
• C) The up-regulation of integrin ligands such as VLA-4 on the blood vessel endothelial cells
• D) The shared expression of chemokine receptors on these different cell types
• E) The shared expression of S1PR1 on these cells, recruiting them out of lymphoid tissues

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