To Avoid the Potential for Activating Self-Reactive T Cells That

question 16

Essay

To avoid the potential for activating self-reactive T cells that might cause autoimmunity, naive T cell activation has stringent requirements for co-stimulatory signals in addition to the engagement of T-cell receptors with peptide:MHC complexes. Yet this requirement is abandoned once T cells have differentiated into effector cells. Name two effector T cell functions that would fail if effector T cells also required T-cell receptor signals plus co-stimulatory signals through CD28 to elicit their effector responses.

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Definitions:

Beta

A measure of a stock's volatility in relation to the overall market, indicating its level of risk associated with market movements.

Risk-Free Rate

The return on investment with no risk of financial loss, traditionally associated with government bonds.

Expected Rate

The anticipated rate of return on an investment, often based on historical data or statistical analysis.

Market Risk Premium

The additional return investors expect for holding a risky market portfolio instead of risk-free assets.