Chimeric Mice Are Generated Where Approximately 50% of the Cells

question 29

Essay

Chimeric mice are generated where approximately 50% of the cells in the animal are genetically MHC class I-deficient. The other 50% are deficient for the herpes virus receptor, HVEM, but do express MHC class I molecules. When these mice are infected with herpesvirus by intraperitoneal injection, a robust virus-specific CD8 T cell response is detected at day 7 post-infection in the spleens of the infected mice. Which cells are presenting herpesvirus antigens to prime the CD8 T cell response, and how did they acquire the viral antigens? Microbe-induced TLR signaling in tissue-resident dendritic cells induces their migration to lymphoid organs and enhances antigen processing

---

Definitions:

Muscle Tissue Type

A classification of muscle tissue into three main types: skeletal, cardiac, and smooth, each with distinct physiological and anatomical characteristics.

Cardiac

Relating to or affecting the heart.

Tissue

Groups of similar cells and their extracellular matrix from the same origin that together carry out a specific function.

Neuroglial Cells

Non-neuronal cells in the nervous system that provide support, nourishment, and protection for neurons.