Individuals That Overexpress the Cytokine BAFF Show Increased Susceptibility to Autoimmune

question 6

Multiple Choice

Individuals that overexpress the cytokine BAFF show increased susceptibility to autoimmune diseases such as Sjögren's syndrome, a disease that targets the exocrine glands that produce saliva, tears, and other bodily secretions. If one examined the circulating antibodies in these patients, one would expect to find:

• A) Increased development of B cells in the bone marrow
• B) A failure of receptor editing of immunoglobulin light chain genes in the bone marrow
• C) An increased rate of immature B cell export from the bone marrow
• D) Reduced B-cell receptor signaling following strong cross-linking of the receptor
• E) An increased number of circulating mature autoreactive B cells

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