Two Mutant Lines of Mice Have Been Identified, Each of Which

question 16

Multiple Choice

Two mutant lines of mice have been identified, each of which has a defect in T cell development. The subsets of thymocytes found in each mutant mouse line are shown in Figure

To narrow down the possible defects in each mutant line, a series of bone marrow chimeras are made in which bone marrow from one strain of mice (the ‘donor’ strain) is used to reconstitute a second strain (the ‘recipient’ strain) , immediately following the irradiation of the recipient strain to eliminate its own hematopoietic cells. In this procedure, the resulting chimeras have hematopoietic cells that are 100% derived from the donor strain, and all other cells and tissues are derived from the recipient strain. The thymocyte profiles of the series of bone marrow chimeras is shown in Figure in each case the label at the top of each FACS plot refers to ‘donor bone marrow recipient’:

-A potential candidate molecule for the gene that is defective in Mutant-2 is:

• A) CD4
• B) MHC class II
• C) Th-POK
• D) MHC class I
• E) Runx3

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Definitions:

Stability and Change

Refers to the dynamic nature of systems, processes, or entities where certain attributes remain constant while others vary over time.

Menopause

A natural biological process marking the end of a woman's menstrual cycles and fertility, typically occurring in the late 40s or early 50s.

Cross-Cultural Research

The examination and comparison of behaviors, traditions, or psychological phenomena across different cultures.

Growth And Change

The process of physical, emotional, or intellectual development and transformation over time.