Experiments Performed with T-Cell Receptor Transgenic Mice Identified the Fate

question 34

Multiple Choice

Experiments performed with T-cell receptor transgenic mice identified the fate of developing thymocytes that failed positive selection. Based on these findings, examination of thymocytes in MHC class I-MHC class II-deficient mice (lacking all MHC class I and class II expression in the thymus) would show:

• A) A 100-fold decrease in total thymocytes numbers
• B) A block in T cell development at the CD4^-CD8^- double-negative stage
• C) Normal numbers and subsets of thymocytes and peripheral T cells
• D) Normal numbers of thymocytes, but no peripheral T cells
• E) A block in T cell development at the CD4⁺CD8⁺ double-positive stage

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