A New Strain of Immunodeficient Mice Has Been Discovered, and Found

question 35

Multiple Choice

A new strain of immunodeficient mice has been discovered, and found to have T cells that are unresponsive to TCR stimulation. The T cells from these mice have normal levels of the TCR complex on their surface, but when this TCR is stimulated, the cells fail to secrete IL-2. As a first step in determining the signaling defect responsible for this immunodeficiency, the T cells are stimulated with a phorbol ester (PMA) and Ionomycin. It is found that this treatment elicits IL-2 production by the immunodeficient T cells. Based on this information, candidate genes that could be mutated in these T cells include all of the following EXCEPT:

• A) ZAP-70
• B) PLC-\(\gamma\)
• C) SLP-76
• D) ITK
• E) Calcineurin

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Definitions:

Working Interview

An interview where the applicant engages in an activity related to the job they're applying for.

Job-sample Interview

An interview technique where candidates are asked to perform tasks or work activities that are part of the job they are applying for.

Selection Stage

A phase in the recruitment process where candidates are evaluated and chosen based on their qualifications, experience, and suitability for the job.

Employment Interviews

Formal meetings between employers and job applicants to assess the suitability of candidates for available positions.