Humans with Defective Expression of the Integrin LFA-1 Have an Immunodeficiency

question 18

Multiple Choice

Humans with defective expression of the integrin LFA-1 have an immunodeficiency disease characterized by the failure of lymphocytes and granulocytes to migrate to tissues at sites of infection or inflammation. A similar immunodeficiency would be expected if individuals had mutations disrupting the gene for:

• A) CD3\(\zeta\)
• B) The complement receptor, CD21
• C) WASp
• D) Rap1
• E) SLP-76

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