A New Strain of Immunodeficient Mice Has Been Discovered, and Found

question 35

Multiple Choice

A new strain of immunodeficient mice has been discovered, and found to have T cells that are unresponsive to TCR stimulation. The T cells from these mice have normal levels of the TCR complex on their surface, but when this TCR is stimulated, the cells fail to secrete IL-2. As a first step in determining the signaling defect responsible for this immunodeficiency, the T cells are stimulated with a phorbol ester (PMA) and Ionomycin. It is found that this treatment elicits IL-2 production by the immunodeficient T cells. Based on this information, candidate genes that could be mutated in these T cells include all of the following EXCEPT:

• A) ZAP-70
• B) PLC-\(\gamma\)
• C) SLP-76
• D) ITK
• E) Calcineurin

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Definitions:

Coaching Technique

A method of guiding an individual or group towards achieving specific goals or improving performance through feedback, instruction, and encouragement.

Enthusiasm

Intense and eager enjoyment, interest, or approval.

High Performance

Achieving significantly better outcomes or efficiency than what is considered standard.

Noble Cause

A goal or principle considered to be morally righteous and worthy of pursuit.