Peptide Editing Is an Important Component of Antigen Presentation for Both

question 16

Multiple Choice

Peptide editing is an important component of antigen presentation for both MHC class I and MHC class II pathways, as it drives the preferential presentation of high-affinity binding peptides. For MHC class II peptide editing, HLA-DM plays a key role. In the absence of HLA-DM:

• A) MHC class II molecules traffic to the cell surface with CLIP in their binding sites.
• B) No MHC class II molecules are released to traffic to the cell surface.
• C) MHC class II molecules bind to HLA-DO and are inhibited from binding peptides.
• D) Pathogens can evade the immune system by blocking peptide exchange on MHC class II.
• E) HLA-DO competes for high-affinity binding peptides with MHC class II molecules and blocks antigen presentation.

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Definitions:

Dyscalculia

Unusual difficulty with math, probably originating from a distinct part of the brain.

Attention-Deficit/Hyperactivity Disorder

A neurodevelopmental disorder characterized by patterns of inattention, hyperactivity, and impulsivity that are more severe than typically observed in individuals at a comparable level of development.

Attention-Deficit/Hyperactivity Disorder

A neurodevelopmental disorder characterized by a pattern of inattention and/or hyperactivity-impulsivity that interferes with functioning or development.

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A rare and severe form of schizophrenia that manifests in children, characterized by hallucinations, delusions, and cognitive difficulties.