The MARCH-1 E3-Ubiquitin Ligase Is Expressed in B Cells, Dendritic

question 29

Multiple Choice

The MARCH-1 E3-ubiquitin ligase is expressed in B cells, dendritic cells, and macrophages. The pathway regulated by MARCH-1 is targeted by some pathogens in an immune evasion strategy. In this strategy, the pathogens encode:

• A) A protein that induces degradation of MARCH-1
• B) A protein that mimics MARCH-1 and functions similarly
• C) A protein that binds to MARCH-1 and inhibits its function
• D) A protein that is induced by IL-10 in macrophages and dendritic cells
• E) A protein that induces degradation of CD86

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