The Experiment Shown in Figure Uses Two Strains of Mice

question 4

Multiple Choice

The experiment shown in Figure uses two strains of mice that differ in their MHC genes. Strain A is H-2^a and Strain B is H-2^b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2^a or H-2^b; in each case, the target cells are either uninfected or infected with LCMV. After a four-hour incubation of T cells with target cells, the percentage of target cells lysed by the T cells is shown in the graph. The explanation for the results of this experiment is:

• A) Mice of strain B do not make a T cell response to LCMV.
• B) Mice of strain A make a more robust T cell response to LCMV than mice of strain B.
• C) Target cells that express H-2^b cannot be infected with LCMV.
• D) T cells from mice of strain A only recognize viral peptides on target cells expressing H-2^a.
• E) LCMV peptides do not bind to MHC class I molecules from H-2^b mice.

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