The Experiment Shown in Figure Uses Two Strains of Mice

question 4

Multiple Choice

The experiment shown in Figure uses two strains of mice that differ in their MHC genes. Strain A is H-2^a and Strain B is H-2^b. Mice of each strain are infected with the virus LCMV, and T cells are isolated at day 8 post-infection. These T cells are mixed with target cells that express either H-2^a or H-2^b; in each case, the target cells are either uninfected or infected with LCMV. After a four-hour incubation of T cells with target cells, the percentage of target cells lysed by the T cells is shown in the graph. The explanation for the results of this experiment is:

• A) Mice of strain B do not make a T cell response to LCMV.
• B) Mice of strain A make a more robust T cell response to LCMV than mice of strain B.
• C) Target cells that express H-2^b cannot be infected with LCMV.
• D) T cells from mice of strain A only recognize viral peptides on target cells expressing H-2^a.
• E) LCMV peptides do not bind to MHC class I molecules from H-2^b mice.

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Definitions:

Csikszentmihalyi

A psychologist best known for his theory of flow, a state in which people are so involved in an activity that nothing else seems to matter.

Flow

The feeling of oneness with an activity that allows an individual to uniquely experience an event or activity by becoming totally engaged in the process; term was coined by Mihaly Csikszentmihalyi.

Work

The effort applied towards completing tasks or producing goods and services, often for compensation.

Arthur Koestler

A British-Hungarian writer known for works exploring the intersection of science, politics, and creativity, including the book "The Act of Creation."