Many Different NOD-Like Receptors, Including Several with Pyrin Domains and Several

question 3

Multiple Choice

Many different NOD-like receptors, including several with pyrin domains and several with HIN domains, can function to trigger inflammasome assembly leading to the activation of caspase-1. The reason for many different sensors in this innate response system is that:

• A) Each NOD-like receptor is expressed in a different set of phagocytic cells, depending on its tissue location.
• B) Each NOD-like receptor resides in a different intracellular compartment.
• C) Each NOD-like receptor performs a different step in the multi-step cascade leading to inflammasome activation.
• D) Each NOD-like receptor binds to a different adapter protein and triggers a different form of the inflammasome.
• E) Each NOD-like receptor recognizes different PAMPs and is activated by different pathogens.

---

Definitions:

New Perspective

A fresh or innovative way of viewing or thinking about something, often leading to different conclusions or approaches.

Genuine Crisis

A critical situation that is authentic and poses significant risk or danger, requiring immediate attention and action.

Charismatic Leadership

A leadership style characterized by an individual's ability to inspire and motivate followers through their vision, communication skills, and personal charisma.

Precipitate A Crisis

To cause a sudden crisis or emergency situation through one's actions or decisions.