Many Different NOD-Like Receptors, Including Several with Pyrin Domains and Several

question 3

Multiple Choice

Many different NOD-like receptors, including several with pyrin domains and several with HIN domains, can function to trigger inflammasome assembly leading to the activation of caspase-1. The reason for many different sensors in this innate response system is that:

• A) Each NOD-like receptor is expressed in a different set of phagocytic cells, depending on its tissue location.
• B) Each NOD-like receptor resides in a different intracellular compartment.
• C) Each NOD-like receptor performs a different step in the multi-step cascade leading to inflammasome activation.
• D) Each NOD-like receptor binds to a different adapter protein and triggers a different form of the inflammasome.
• E) Each NOD-like receptor recognizes different PAMPs and is activated by different pathogens.

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