The Classical Complement Pathway Is Initiated by C1q Binding to the Surface

question 28

Multiple Choice

The classical complement pathway is initiated by C1q binding to the surface of a pathogen. In some cases, C1q can directly bind the pathogen, for instance by recognizing proteins of bacterial cell walls, but in most cases C1q binds to IgM antibodies that are bound to the pathogen surface. How does this IgM-binding feature of C1q contribute to rapid, innate immune responses rather than to slow, adaptive responses?

• A) C1q induces B lymphocytes to begin secreting antibody within hours of pathogen exposure.
• B) Natural antibody that binds to many microbial pathogens is produced prior to pathogen exposure.
• C) C1q binds to C-reactive protein which then binds to IgM on the pathogen surface.
• D) C1q directly induces inflammation, recruiting phagocytes and antibodies from the blood into the infected tissue.
• E) C1q binds to dendritic cells in the infected tissue, inducing them to secrete inflammatory cytokines.

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