How Are Gluconeogenesis and Glycolysis Coordinated by Nucleotides

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The Answer is ATP inhibits glycolysis at PFK, while ADP inhibits the flow of carbon from pyruvate to glucose at pyruvate carboxylase and phosphoenolpyruvate carboxykinase. When ADP levels are high, adenylate kinase converts ADP to AMP and ATP. The increase in AMP (only in a low-energy state) results in the inhibition of gluconeogenesis and activates glycolysis in the liver.

How Are Gluconeogenesis and Glycolysis Coordinated by Nucleotides

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