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For the hydrolysis of ATP to ADP + ℗i, the free-energy change is -7.3 kcal/mol under standard conditions (1 M concentration of both reactants and products) . In the cellular environment, however, the free-energy change is about -13 kcal/mol. What can we conclude about the free-energy change for the formation of ATP from ADP and ℗i under cellular conditions?
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