Use the Following Information to Answer the Few Questions

question 44

Multiple Choice

Use the following information to answer the few questions.
The herpes viruses are very important enveloped DNA viruses that cause disease in all vertebrate species and in some invertebrates such as oysters. Some of the human ones are herpes simplex (HSV) I and II, causing facial and genital lesions, and the varicella-zoster (VSV) , causing chicken pox and shingles. Each of these three actively infect nervous tissue. Primary infections are fairly mild, but the virus is not then cleared from the host; rather, viral genomes are maintained in cells in a latent phase. The virus can then reactivate, replicate again, and be infectious to others.
-In order to be able to remain latent in an infected live cell, HSV must be able to shut down what process?

• A) DNA replication
• B) transcription of viral genes
• C) apoptosis of a virally infected cell
• D) all immune responses
• E) interaction with histones

---

Definitions:

Wilcoxon Signed Rank Test

A statistical analysis method void of parametric requirements, designed to assess whether two associated samples, matched pairs, or recurrent measurements on an individual sample exhibit differences in their mean rank in the population.

Rank Sums

A non-parametric statistical measure used to compare the distributions of two independent samples by ranking all observations together and then summing ranks for observations belonging to each sample.

Standardized Test Statistic

A calculated value used to determine the relative distance of a data point or sample from the mean of a population, expressed in terms of the standard deviation of the population.

Positive Differences

The result obtained when subtracting a smaller number from a larger number in each pair of a data set.