An Aminoacyl-TRNA Synthetase Is the Enzyme That Catalyzes the Attachment

question 69

Multiple Choice

An aminoacyl-tRNA synthetase is the enzyme that catalyzes the attachment of a particular amino acid to its corresponding tRNA. This reaction requires energy from ATP. The enzyme initially binds the amino acid and ATP, but it is unable to bind the tRNA. Which of the following would be a likely mechanism by which the enzyme ultimately binds the tRNA and attaches the amino acid?

• A) Transfer of the ATP to the tRNA opens the active site to allow the tRNA to bind.
• B) Hydrolysis of ATP activates the amino acid, which is released, opening up the active site to allow binding of the tRNA.
• C) Hydrolysis of ATP phosphorylates the amino acid and results in a conformational change in the active site, which allows the tRNA to bind.
• D) Alteration in the conformation of the tRNA allows it to bind to the active site along with the amino acid and ATP.

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