HIV's Genome of RNA Includes the Code for Reverse Transcriptase

question 39

Multiple Choice

HIV's genome of RNA includes the code for reverse transcriptase (RT) , an enzyme that acts early in infection to synthesise a DNA genome off of an RNA template. The HIV genome also codes for protease (PR) , an enzyme that acts later in infection by cutting long viral polyproteins into smaller, functional proteins. Both RT and PR represent potential targets for antiretroviral drugs. Drugs called nucleoside analogues (NA) act against RT, whereas drugs called protease inhibitors (PI) act against PR.
Which of the following treatment options would most likely avoid the evolution of drug-resistant HIV (assuming no drug interactions or side effects) ?

• A) Use a series of NAs, one at a time, and change about once a week.
• B) Use a single PI, but slowly increase the dosage over the course of a week.
• C) Use high doses of NA and a PI at the same time for a period not to exceed one day.
• D) Use moderate doses of NA and two different PIs at the same time for several months.

---

Definitions:

Blepharitis

An inflammation of the eyelids, which can cause irritation, redness, and dandruff-like scales on eyelashes.

Crusted Eyelids

A condition characterized by the buildup of dry, flaky skin or discharge on the eyelids, often associated with infections or inflammations.

Myopia

A refractive error in the eye where light focuses in front of, instead of on, the retina, causing distant objects to appear blurred.

Antibiotic Eyedrops

Medicated drops used to treat bacterial infections of the eye, preventing or limiting the spread of bacteria.